Samuel E. Marsh

Bio

I’m a hard-working, collaborative, and motivated neuroscientist and neuroimmunologist with 10+ years studying neurodegeneration, aging, and CNS immunity. I have wide-ranging expertise from molecular neuroscience, animal models & behavior, and single-cell and bulk transcriptomics and analysis.

I am currently a postdoctoral fellow in the lab of Dr. Beth Stevens, where my work centers around understanding immune system dysfunction in Alzheimer’s disease and aging. My projects are focused on the application single cell sequencing (scRNA-seq) technology to understand the gene expression changes that occur during aging and disease. Utilizing the unparalleled resolution of scRNA-seq to understand the complex cell-to-cell interactions that mediate disease pathogenesis. My projects involve both animal models and human subjects in an attempt to better bridge the gap between basic science and clinical translation.

I graduated from Northeastern University with B.S. in Behavioral Neuroscience and received my Ph.D. in Neurobiology & Behavior from UC Irvine. My doctoral work in the lab of Dr. Mathew Blurton-Jones focused on the role of the peripheral adaptive immune system in Alzheimer’s disease. My research uncovered a novel role by which peripheral adaptive immune signaling modulates microglial function to alter the pathogenesis of Alzheimer’s disease.

Education

The University of California, Irvine | Irvine, CA

Ph.D. in Neurobiology | September 2011 - September 2016

Northeastern University | Boston, MA

B.S. in Behavioral Neuroscience | September 2006 - April 2010

Experience

Boston Children’s Hospital/Harvard Medical School | Postdoctoral Fellow | September 2017 - Present

The University of California, Irvine | Postdoctoral Fellow | September 2016 - September 2017

Publications

Selected bibliography can be found below and full bibliography can be found here.

Primary Research

Gazestani V, Kamath T, Nadaf NM, Dougalis A, Burris SJ, Rooney B, Junkkari A, Vanderburg C, Pelkonen A, Gomez-Budia M, Välimäki NN, Rauramaa T, Therrien M, Koivisto AM, Tegtmeyer M, Herukka SK, Abdulraouf A, Marsh SE, Hiltunen M, Nehme R, Malm T, Stevens B, Leinonen V, Macosko EZ (2023). Early Alzheimer’s disease pathology in human cortex involves transient cell states. Cell, 186(20):4438–4453.e23. PMID: 37774681. doi.org/10.1016/j.cell.2023.08.005.
Journal Link | Free PDF Full Text | SI Tables | Data Link | Code | PubMed

💥Marsh SE, Walker, AJ, Kamath, T, Dissing-Olesen, L, Hammond, TR, de Soysa, TY, Young, AMH, Murphy, S, Abdulraouf, A, Nadaf, N, Dufort, C, Walker, AC, Lucca, LE, Kozareva, V, Vanderburg, C, Hong, S, Bulstrode, H, Hutchinson, PJ, Gaffney, DJ, Hafler, DA, Franklin, RJM, Macosko, EZ, Stevens, B (2022). Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain. Nature Neuroscience 25(3), 306-316.
Journal Link | Free PDF Full Text | PDF SI Figures & Notes/Discussion | Code | PubMed |

Hammond TR, Dufort C, Dissing-Olesen L, Giera S, Young A, Wysoker A, Walker AJ, Gergits F, Segel M, Nemesh J, Marsh SE, Saunders A, Macosko E, Ginhoux F, Chen J, Franklin RJM, Piao X, McCarroll SA, and Stevens B (2019). Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Immunity 50(1): 253-271.e6.
Open Access Full Text | PDF Full Text & SI Info | Processed Data Link | PubMed

Abud EM, Ramirez R, Martinez E, Healy L, Nguyen C, Newman S, Yeromin A, Scarfone V, Marsh SE, Fimbres C, Caraway C, Fote G, Mandany A, Agrawal A, Kayed R, Ghylys K, Cahalan M, Cummings B, Antel J, Mortazavi A, Carson M, Poon W, Blurton-Jones M (2017). iPSC-derived human microglia-like cells to study neurological diseases. Neuron 94(2): 278-293.
Open Access Full Text | PDF Full Text & SI Info | PubMed

Marsh SE, Yeung ST, Torres MD, Lau L, Davis JD, Monuki ES, Poon WW, Blurton-Jones M (2017). HuCNS-SC human NSCs fail to terminally differentiate, form ectopic clusters, and provide no cognitive benefits in a transgenic model of Alzheimer’s disease. Stem Cell Reports 8(2):235-248.
Open Access Full Text | PDF Full Text & SI Info | PubMed

💥Marsh SE, Abud, EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane T, Inlay MA, Poon WW, Blurton-Jones M (2016). The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglia function. Proceedings of the National Academy of Sciences USA 113(9):E1316–25.
Open Access Full Text | PDF Full Text | PDF SI Info | PubMed

Reviews

💥Liddelow S*, Marsh SE* , Stevens B* (2020). Microglia and astrocytes in health and disease: Dynamic Duo or Partners in Crime? Trends in Immunology 41(9): 820-835.
*Equal Contribution
Journal Link | Free PDF Full Text | PubMed

💥Hammond TR*, Marsh SE*, Stevens B (2019). Immune Signaling in Neurodegeneration. Immunity 50(4): 955-974.
*Equal Contribution
Open Access Full Text | PDF Full Text | PubMed

Marsh SE & Blurton-Jones, M (2012). Examining the mechanisms that link beta-amyloid and alpha-synuclein pathologies. Alzheimer’s Research & Therapy 4(2), 11a.
Open Access Full Text | PDF Full Text | PubMed

Samuel E. Marsh

Bio

I’m a hard-working, collaborative, and motivated neuroscientist and neuroimmunologist with 10+ years studying neurodegeneration, aging, and CNS immunity. I have wide-ranging expertise from molecular neuroscience, animal models & behavior, and single-cell and bulk transcriptomics and analysis.

I am currently a postdoctoral fellow in the lab of Dr. Beth Stevens, where my work centers around understanding immune system dysfunction in Alzheimer’s disease and aging. My projects are focused on the application single cell sequencing (scRNA-seq) technology to understand the gene expression changes that occur during aging and disease. Utilizing the unparalleled resolution of scRNA-seq to understand the complex cell-to-cell interactions that mediate disease pathogenesis. My projects involve both animal models and human subjects in an attempt to better bridge the gap between basic science and clinical translation.

I graduated from Northeastern University with B.S. in Behavioral Neuroscience and received my Ph.D. in Neurobiology & Behavior from UC Irvine. My doctoral work in the lab of Dr. Mathew Blurton-Jones focused on the role of the peripheral adaptive immune system in Alzheimer’s disease. My research uncovered a novel role by which peripheral adaptive immune signaling modulates microglial function to alter the pathogenesis of Alzheimer’s disease.

Education

The University of California, Irvine | Irvine, CA

Ph.D. in Neurobiology | September 2011 - September 2016

Northeastern University | Boston, MA

B.S. in Behavioral Neuroscience | September 2006 - April 2010

Experience

Boston Children’s Hospital/Harvard Medical School | Postdoctoral Fellow | September 2017 - Present

The University of California, Irvine | Postdoctoral Fellow | September 2016 - September 2017

Publications

Selected bibliography can be found below and full bibliography can be found here.

Primary Research

Gazestani V, Kamath T, Nadaf NM, Dougalis A, Burris SJ, Rooney B, Junkkari A, Vanderburg C, Pelkonen A, Gomez-Budia M, Välimäki NN, Rauramaa T, Therrien M, Koivisto AM, Tegtmeyer M, Herukka SK, Abdulraouf A, Marsh SE, Hiltunen M, Nehme R, Malm T, Stevens B, Leinonen V, Macosko EZ (2023). Early Alzheimer’s disease pathology in human cortex involves transient cell states. Cell, 186(20):4438–4453.e23. PMID: 37774681. doi.org/10.1016/j.cell.2023.08.005.
Journal Link | Free PDF Full Text | SI Tables | Data Link | Code | PubMed

💥Marsh SE, Walker, AJ, Kamath, T, Dissing-Olesen, L, Hammond, TR, de Soysa, TY, Young, AMH, Murphy, S, Abdulraouf, A, Nadaf, N, Dufort, C, Walker, AC, Lucca, LE, Kozareva, V, Vanderburg, C, Hong, S, Bulstrode, H, Hutchinson, PJ, Gaffney, DJ, Hafler, DA, Franklin, RJM, Macosko, EZ, Stevens, B (2022). Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain. Nature Neuroscience 25(3), 306-316.
Journal Link | Free PDF Full Text | PDF SI Figures & Notes/Discussion | Code | PubMed |

Hammond TR, Dufort C, Dissing-Olesen L, Giera S, Young A, Wysoker A, Walker AJ, Gergits F, Segel M, Nemesh J, Marsh SE, Saunders A, Macosko E, Ginhoux F, Chen J, Franklin RJM, Piao X, McCarroll SA, and Stevens B (2019). Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Immunity 50(1): 253-271.e6.
Open Access Full Text | PDF Full Text & SI Info | Processed Data Link | PubMed

Abud EM, Ramirez R, Martinez E, Healy L, Nguyen C, Newman S, Yeromin A, Scarfone V, Marsh SE, Fimbres C, Caraway C, Fote G, Mandany A, Agrawal A, Kayed R, Ghylys K, Cahalan M, Cummings B, Antel J, Mortazavi A, Carson M, Poon W, Blurton-Jones M (2017). iPSC-derived human microglia-like cells to study neurological diseases. Neuron 94(2): 278-293.
Open Access Full Text | PDF Full Text & SI Info | PubMed

Marsh SE, Yeung ST, Torres MD, Lau L, Davis JD, Monuki ES, Poon WW, Blurton-Jones M (2017). HuCNS-SC human NSCs fail to terminally differentiate, form ectopic clusters, and provide no cognitive benefits in a transgenic model of Alzheimer’s disease. Stem Cell Reports 8(2):235-248.
Open Access Full Text | PDF Full Text & SI Info | PubMed

💥Marsh SE, Abud, EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane T, Inlay MA, Poon WW, Blurton-Jones M (2016). The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglia function. Proceedings of the National Academy of Sciences USA 113(9):E1316–25.
Open Access Full Text | PDF Full Text | PDF SI Info | PubMed

Reviews

💥Liddelow S*, Marsh SE* , Stevens B* (2020). Microglia and astrocytes in health and disease: Dynamic Duo or Partners in Crime? Trends in Immunology 41(9): 820-835.
*Equal Contribution
Journal Link | Free PDF Full Text | PubMed

💥Hammond TR*, Marsh SE*, Stevens B (2019). Immune Signaling in Neurodegeneration. Immunity 50(4): 955-974.
*Equal Contribution
Open Access Full Text | PDF Full Text | PubMed

Marsh SE & Blurton-Jones, M (2012). Examining the mechanisms that link beta-amyloid and alpha-synuclein pathologies. Alzheimer’s Research & Therapy 4(2), 11a.
Open Access Full Text | PDF Full Text | PubMed