Primary Research

Gazestani V, Kamath T, Nadaf NM, Dougalis A, Burris SJ, Rooney B, Junkkari A, Vanderburg C, Pelkonen A, Gomez-Budia M, Välimäki NN, Rauramaa T, Therrien M, Koivisto AM, Tegtmeyer M, Herukka SK, Abdulraouf A, Marsh SE, Hiltunen M, Nehme R, Malm T, Stevens B, Leinonen V, Macosko EZ (2023). Early Alzheimer’s disease pathology in human cortex involves transient cell states. Cell, 186(20):4438–4453.e23. PMID: 37774681. doi.org/10.1016/j.cell.2023.08.005.
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Dolan M-J, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, Marsh SE, Goeva A, Lojek NM, Murphy S, White CM, Joung J, Liu B, Limone F, Eggan K, Hacohen N, Bernstein BE, Glass CK, Leinonen V, Blurton-Jones M, Zhang F, Epstein CB, Macosko EZ, Stevens B (2023). Exposure of iPSC-derived human microglia to brain substrates enables generation and manipulation of diverse transcriptional states in vitro. Nature Immunology 24(8):1382–1390. PMID: 37500887. doi.org/10.1038/s41590-023-01558-2.
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💥Marsh SE, Walker, AJ, Kamath, T, Dissing-Olesen, L, Hammond, TR, de Soysa, TY, Young, AMH, Murphy, S, Abdulraouf, A, Nadaf, N, Dufort, C, Walker, AC, Lucca, LE, Kozareva, V, Vanderburg, C, Hong, S, Bulstrode, H, Hutchinson, PJ, Gaffney, DJ, Hafler, DA, Franklin, RJM, Macosko, EZ, Stevens, B (2022). Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain. Nature Neuroscience 25(3), 306-316.
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Quershi YH, Berman DE, Marsh SE, Klein RL, Patel VM, Simoes S, Kannan S, Petsko GA, Stevens B, Small SA (2022). The neuronal retromer can regulate both neuronal and Microglial phenotypes of Alzheimer’s disease. Cell Reports 38(3) 110262.
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Shukla AK, McIntyre LL, Marsh SE, Schneider CA, Hoover EM, Walsh CT, Lodoen MB, Blurton-Jones M, Inlay MA (2019). CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer’s disease. Glia 67(5): 844-856.
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Hammond TR, Dufort C, Dissing-Olesen L, Giera S, Young A, Wysoker A, Walker AJ, Gergits F, Segel M, Nemesh J, Marsh SE, Saunders A, Macosko E, Ginhoux F, Chen J, Franklin RJM, Piao X, McCarroll SA, and Stevens B (2019). Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes. Immunity 50(1): 253-271.e6.
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Mathur V, Burai R, Vest RT, Bonanno LN, Lehallier B, Zardeneta M, Mistry KN, Do D, Marsh SE, Abud EM, Blurton-Jones M, Li L, Lashuel HA, Wyss-Coray T (2017). Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation. Neuron 96(6): 1290-1302.
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Abud EM, Ramirez R, Martinez E, Healy L, Nguyen C, Newman S, Yeromin A, Scarfone V, Marsh SE, Fimbres C, Caraway C, Fote G, Mandany A, Agrawal A, Kayed R, Ghylys K, Cahalan M, Cummings B, Antel J, Mortazavi A, Carson M, Poon W, Blurton-Jones M (2017). iPSC-derived human microglia-like cells to study neurological diseases. Neuron 94(2): 278-293.
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Goldberg NRS, Marsh SE, Ochaba J, Shelley BC, Davtyan H, Thompson LM, Steffan JS, Svendsen CN, Blurton-Jones M (2017). Human glial progenitor transplantation recuses behavioral deficits and alters alpha-synuclein oligomers in an immune-deficient model of Dementia with Lewy Bodies. Stem Cells Translational Medicine 6:1477-90.
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Marsh SE, Yeung ST, Torres MD, Lau L, Davis JD, Monuki ES, Poon WW, Blurton-Jones M (2017). HuCNS-SC human NSCs fail to terminally differentiate, form ectopic clusters, and provide no cognitive benefits in a transgenic model of Alzheimer’s disease. Stem Cell Reports 8(2):235-248.
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💥Marsh SE, Abud, EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane T, Inlay MA, Poon WW, Blurton-Jones M (2016). The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglia function. Proceedings of the National Academy of Sciences USA 113(9):E1316–25.
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Reviews

💥Colonna M, Konopka G, Liddelow SA, Nowakowski T, Awatramani R, Bateup HS, Caldwell CR, Caglayan E, Chen JL, Gillis J, Kampmann M, Krienen F, Marsh SE, Monje M, O’Dea MR, Patani R, Pollen AA, Quintana FJ, Scavuzzo M, Schmitz M, Sloan S, Tesar PJ, Tollkuhn J, Tosches MA, Urbanek ME, Werner JM, Bayraktar OA, Gokce O, Habib N (2024; in press). Implementation and validation of single-cell genomics experiments in neuroscience*. Nature Neuroscience.
^{*Part of series on use of single cell genomics in neuroscience. See here for link to December issue containing other pieces.}

Kloske CM, Barnum CJ, Batista AF, Bradshaw EM, Brickman AM, Bu G, Dennison J, Gearon MD, Goate AM, Haass C, Heneka MT, Hu WT, Huggins LKL, Jones NS, Koldamova R, Lemere CA, Liddelow SA, Marcora E, Marsh SE, Nielsen HM, Petersen KK, Petersen M, Piña-Escudero SD, Qiu WQ, Quiroz YT, Reiman E, Sexton C, Tansey MG, Tcw J, Teunissen CE, Tijms BM, van der Kant R, Wallings R, Weninger SC, Wharton W, Wilcock DM, Wishard TJ, Worley SL, Zetterberg H, Carrillo MC (2023). APOE and immunity: Research highlights. Alzheimers Dement, PMID: 36975090. 10.1002/alz.13020.
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💥Liddelow S*, Marsh SE* , Stevens B* (2020). Microglia and astrocytes in health and disease: Dynamic Duo or Partners in Crime? Trends in Immunology 41(9): 820-835.
^{*Equal Contribution}
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💥Hammond TR*, Marsh SE*, Stevens B (2019). Immune Signaling in Neurodegeneration. Immunity 50(4): 955-974.
^{*Equal Contribution}
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Marsh SE & Blurton-Jones M (2017). Neural stem cell therapy for neurodegenerative disorders: The importance of neurotrophic support. Neurochemistry International 106:94-100.
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Marsh SE & Blurton-Jones, M (2012). Examining the mechanisms that link beta-amyloid and alpha-synuclein pathologies. Alzheimer’s Research & Therapy 4(2), 11a.
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